Long-term hearing outcomes after recurrent acute otitis media during early childhood.

OBJECTIVE: To survey long-term hearing outcomes and middle ear pathology in a 30-year follow-up in individuals with onset of recurrent acute otitis media (rAOM) before three years of age. METHODS: 28 adults, aged 30.1-31.8 years, who originally - at the age of 12-32 months - participated in a study on rAOM between 1979 and 1983, were re-examined regarding self-reported ear problems, current tympanic membrane changes and audiology. Thirteen subjects had suffered from rAOM during early childhood and 15 subjects served as a control group. RESULTS: Recurrent acute otitis media subjects reported hearing problems comparable to those of the controls. Pure tone audiometry, at 125-8000 Hz, did not differ between groups. The rAOM group had a trend for impaired high-frequency (9000-14,000 Hz) threshold levels (9000-14,000 Hz); implying that their cochlear function seemed to have deteriorated. CONCLUSIONS: Adults, who suffered from recurrent acute otitis media as infants, did not show any clinically significant hearing loss for pure tone audiometry when compared to controls, but there was a trend for impaired results regarding extended high frequency audiometry (9-14 kHz). Children suffering from rAOM will be at low risk of developing hearing loss and severe middle ear disease.

Normalized immunoglobulin patterns in adults with recurrent acute otitis media and low IgG2 levels during early childhood.

OBJECTIVES: Children who suffer from recurrent acute otitis media (rAOM) sometimes display low immunoglobulin levels. It is not known whether the differences in immunoglobulin levels remain during adulthood or if rAOM-patients have more episodes of AOM and airway infections as adults. METHODS: A study on adults, with a history of rAOM during childhood, was performed. The immunologic status and individual disposition for upper airway infections were evaluated in 28 subjects who originally participated in a study on rAOM between 1979 and 1983. 13 subjects had suffered from rAOM during early childhood and 15 subjects without rAOM served as a control group. The study included analysis of immunoglobulins in serum and self evaluation regarding susceptibility to infections of the upper airway. RESULTS: There was no difference between the groups neither regarding IgG2 concentrations nor specific antibody levels. No episodes of AOM were reported after 20 years of age in any of the study subjects. The history of airway infections was similar in both groups. CONCLUSIONS: Study subjects who had rAOM combined with low IgG2 levels during childhood had a normalized immunoglobulin pattern as adults.